found 92 skills in registry
SQLite is a self-contained, serverless, zero-configuration embedded SQL database engine. Learn CLI usage, Node.js integration with better-sqlite3, Python's built-in sqlite3 module, and best practices for schema design, indexing, and WAL mode.
You are an expert in Electric SQL, the sync engine that streams Postgres data to local apps in real-time. You help developers build local-first applications where data syncs from Postgres to client-side SQLite/PGlite automatically — enabling instant reads, offline support, and real-time multi-user collaboration using Postgres as the single source of truth with Shape-based partial replication.
Build local-first applications with ElectricSQL — sync Postgres data to client devices in real-time. Use when someone asks to "sync database to client", "local-first app", "ElectricSQL", "offline-first sync", "real-time Postgres sync", "sync Postgres to SQLite", or "build an app that works offline". Covers shape-based sync, real-time subscriptions, offline support, and conflict resolution.
MySQL is the world's most popular open-source relational database management system. Learn installation, SQL queries, indexing strategies, replication setup, and client integration with Node.js (mysql2) and Python (mysql-connector).
Assists with designing schemas, writing performant queries, managing indexes, and operating PostgreSQL databases. Use when working with JSONB, full-text search, window functions, CTEs, row-level security, replication, or performance tuning. Trigger words: postgresql, postgres, sql, database, jsonb, rls, window functions, cte.
Analyze and optimize SQL queries for performance. Use when a user asks to optimize a query, speed up a slow query, analyze a query plan, add indexes, fix N+1 queries, reduce query time, tune database performance, or rewrite SQL for efficiency. Supports PostgreSQL, MySQL, and SQLite.
Work with databases in Python using SQLAlchemy. Use when a user asks to set up a Python ORM, define database models, write async database queries, manage migrations with Alembic, or choose between SQLAlchemy and Django ORM.
Detect and exploit SQL injection with sqlmap. Use when a user asks to test for SQL injection, extract database contents, bypass authentication via SQLi, automate injection testing, or dump database schemas.
Query InterPro for protein family, domain, and functional site annotations. Integrates Pfam, PANTHER, PRINTS, SMART, SUPERFAMILY, and 11 other member databases. Use for protein function prediction, domain architecture analysis, evolutionary classification, and GO term mapping.
Query and analyze scholarly literature using the OpenAlex database. This skill should be used when searching for academic papers, analyzing research trends, finding works by authors or institutions, tracking citations, discovering open access publications, or conducting bibliometric analysis across 240M+ scholarly works. Use for literature searches, research output analysis, citation analysis, and academic database queries.
Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching.
Query cBioPortal for cancer genomics data including somatic mutations, copy number alterations, gene expression, and survival data across hundreds of cancer studies. Essential for cancer target validation, oncogene/tumor suppressor analysis, and patient-level genomic profiling.
Query ChEMBL bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.
Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and safety research.
Query NCBI Gene via E-utilities/Datasets API. Search by symbol/ID, retrieve gene info (RefSeqs, GO, locations, phenotypes), batch lookups, for gene annotation and functional analysis.
Query gnomAD (Genome Aggregation Database) for population allele frequencies, variant constraint scores (pLI, LOEUF), and loss-of-function intolerance. Essential for variant pathogenicity interpretation, rare disease genetics, and identifying loss-of-function intolerant genes.
Query GTEx (Genotype-Tissue Expression) portal for tissue-specific gene expression, eQTLs (expression quantitative trait loci), and sQTLs. Essential for linking GWAS variants to gene regulation, understanding tissue-specific expression, and interpreting non-coding variant effects.
Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.